Berberine May Reduce Weight and Lower Blood Glucose Levels

Berberine is a substance found in plants including goldenseal, barberry, Oregon grape, and others. It has a long history of uses in ancient medicine for skin diseases, infections, and digestive health.  More recently Berberine has been studied for its effects on diabetes and risk factors for heart disease and most recently, it has become popular as a potential weight loss aid.¹ 

A 2022 review of 18 studies that examined the effect of berberine on body weight and 23 that examined its effect on body mass index (BMI; a value based on weight and height that may help determine whether a person has a healthy weight) found significant decreases in both weight and BMI in people who took berberine. Although more studies are needed, the effects on weight were seen primarily in people who took berberine in doses of more than 1 gram per day and for more than 8 weeks.²

In general, when taken orally, berberine is well tolerated; however, it is not without its risks and side effects. The most common adverse effects of berberine include abdominal pain, constipation, diarrhea, nausea, and vomiting. People who are pregnant or breastfeeding should not use berberine, and it should not be given to infants. Berberine can cause or worsen jaundice in newborn infants and could lead to a life-threatening problem called kernicterus. Berberine might also interact with medicines in negative ways.³

There is some evidence that berberine may have a modest effect on lowering blood glucose levels in people with type 2 diabetes and may reduce cholesterol levels. Berberine may have additional beneficial effects on high blood pressure when used in combination with the medication amlodipine.