Category: General

NAD efficiency is increased with RiaGev™

Posted on by Mike Miller

RiaGev is a proprietary compound that has demonstrated enters the NAD+ pathway directly and increases efficiently throughout the body, including muscle and brain.

Nicotinamide adenine dinucleotide (NAD) is a co-factor in the metabolic process and is a crucial element for life and everyday health. Levels of NAD in the body decrease naturally as we age. It declines faster when we are under stress, in an obese state or with any type of disease. Evidence accumulated in the last decade has demonstrated that decreased levels of NAD are correlated with health issues including cognitive decline, neurological disorder, mitochondrial dysfunction, metabolic imbalance and possibly a shortened healthy lifespan.

NAD+ is pivotal for cell life—first as a reusable coenzyme for redox reaction and energy production, second as a consumable substrate in enzymatic reactions regulating crucial biological processes including gene expression, DNA repair, cell death and lifespan, calcium signaling, glucose homeostasis, and circadian rhythms. 

As coenzymes, NAD+ and its related metabolites NAD+H, NAD+P+, and NAD+PH, participate in over 60% of the reactions in cellular metabolism. And their homeostasis is the determinant for oxidation versus reduction and anabolism versus catabolism balances. As a consumable substrate, NAD+ concentration is directly linked with aging and fat composition. And NAD+-consuming enzymes, including PARPs, sirtuins, and CD38, have wide-spread ramification for health and disease. 

The experiment demonstrated that RiaGev effectively increases NAD+, including NAD+, MNN, and NR, levels in the body. For all the organs and tissue analyzed, a positive dose-response occurs between RiaGev and NAD+ metabolites content. The five-day time course experiment indicates that RiaGev increased NAD+ levels and it reached its plateau in blood after four days (8 doses) of oral supplementation.

Women’s Energy Supplements are Out-pacing the Broader Energy Supplement Market

Posted on by Mike Miller

The supplement market is moving towards more sophisticated, targeted products. This movement is demonstrating increasing growth in specialized women’s energy supplements, particularly those addressing fatigue and mental clarity.  The market is projected to grow faster than the broader energy supplement demographic.

The general women’s health supplement market dominated the consumer demographic with over 30% share. Based on the 31-50 age group, which represented nearly 40% of the market, this demographic prioritizes supplements for hormonal balance, skin health, bone density and energy, which is fueling the demand for tailored products. The consumer is purchasing clean label, clinically-backed products that prioritize transparency, efficacy and life-stage specific wellness solutions.

Consumers are more educated about health. As a result they are shifting their purchasing power to supplements that provide preventive healthcare that specifically meet nutritional deficiencies and aging. Women are increasingly incorporating dietary supplements into their daily routines. The value of vitamins and botanical supplements to the consumer is demonstrating significant growth with the most rapid growth in botanical nutraceuticals.

 Plant Science manufactures both liquid and powder supplements, however we are a partner with our clients and as a result we have invested significantly in research and development. We are committed to developing the best products for our clients’ demographic and growth. Check out the Plant Science difference.

 GLP-1 Nature’s Weight Loss

Posted on by Mike Miller

Studies have identified over 42% of Americans are obese. The scope of the U.S. weight demographic explains the explosion of sales of GLP-1 drugs with 12% of the population trying the drugs. Although significant weight-loss results have been identified, 50% of consumers stop using the GLP-1 prescribed drug in the first year with another 25% of patients ceasing its use by the second year, resulting in 75% of consumers ending the use of their prescriptions. As a result consumers have experienced their weight returning.

Studies have shown a range of side effects and even serious complications as a result of the currently approved GLP-1 drugs.1 The documented side effects are predominantly gastrointestinal, and include nausea, diarrhea, constipation, vomiting and include a loss of muscle mass. There are reported adverse events, that include gallbladder disorders and acute pancreatitis.2 In addition, multiple studies identified new risks associated with GLP-1RAs including increased aspiration risk during anesthesia due to delayed gastric emptying and bowel preparation for colonoscopies.

Recent studies on gut bacteria Akkermansia muciniphila have demonstrated its influence on GLP-1 natural production and weight loss.3  Research has also suggested that berberine, a naturally occurring compound in several plants may stimulate the release of GLP-1 and help improve glycemic control, reduce appetite, and support weight loss, making it a promising supplement for managing type 2 diabetes and metabolic disorders.4 Its combination of effects on glucose metabolism and GLP-1 release makes berberine a valuable natural option for metabolic health.

Plant Science uses the latest studies to enhance product development for your consumers.

Berberine May Reduce Weight and Lower Blood Glucose Levels

Posted on by Mike Miller

Berberine is a substance found in plants including goldenseal, barberry, Oregon grape, and others. It has a long history of uses in ancient medicine for skin diseases, infections, and digestive health.  More recently Berberine has been studied for its effects on diabetes and risk factors for heart disease and most recently, it has become popular as a potential weight loss aid.1 

A 2022 review of 18 studies that examined the effect of berberine on body weight and 23 that examined its effect on body mass index (BMI; a value based on weight and height that may help determine whether a person has a healthy weight) found significant decreases in both weight and BMI in people who took berberine. Although more studies are needed, the effects on weight were seen primarily in people who took berberine in doses of more than 1 gram per day and for more than 8 weeks.2

In general, when taken orally, berberine is well tolerated; however, it is not without its risks and side effects. The most common adverse effects of berberine include abdominal pain, constipation, diarrhea, nausea, and vomiting. People who are pregnant or breastfeeding should not use berberine, and it should not be given to infants. Berberine can cause or worsen jaundice in newborn infants and could lead to a life-threatening problem called kernicterus. Berberine might also interact with medicines in negative ways.3

There is some evidence that berberine may have a modest effect on lowering blood glucose levels in people with type 2 diabetes and may reduce cholesterol levels. Berberine may have additional beneficial effects on high blood pressure when used in combination with the medication amlodipine.

Massive Growth Projected for Muscle Recovery Supplements

Posted on by Mike Miller

Workout and recovery supplements continue to grow with projected growth of nearly 8% CAGR to 2034. The muscle recovery market is undergoing rapid growth with the popularity of fitness and sports nutrition. As more people participate in physical activity the demand for efficacious muscle recovery to reduce soreness, repair muscle, and enhance endurance during activity continues to expand.


New supplement types of muscle recovery that include natural, organic, and plant based compound products reach a broader market share of consumers.1 These types of formulations reduce the inherent resistance to trying a new product. Supplemental ingredients to consider for a formulation include: 

1. Branched-chain amino acids for muscle repair. 

2. Glutamine aids in the prevention of muscle wastage. 

3. Creatine helps energy production in muscles, which may lead to muscle growth and strength.

4. Fish oil, which contains omega-3 fatty acids, can reduce muscle soreness and improve range of motion.

5.  Beta-alanie is an amino acid that helps to reduce fatigue and improve exercise performance.

The demographic for muscle recovery includes athletes, active people, and injury rehabilitation patients. “Athletic participation boosts interest in effective recovery supplements globally.”2 Fitness groups and followers have influential social networks and bloggers. This type of network can create a sustainable alliance that grows and retains product consumers. These groups also strengthen the organic growth of the product through trusted testimonials and sources. A functional recovery formula with clinical studies and testimonials is an ideal product to offer as a sample and grow market share. 

Muscle Health from Fava Bean

Posted on by Mike Miller

Using AI technology through the mining of trillions of sequences the discovery of a novel bioactive peptide was found. This network of bioactive peptides is released through the enzymatic hydrolysis of the fava bean. This new protein is trademarked as PeptiStrong.

Clinical studies have demonstrated marked improvement in a number of bone and muscle evaluations:1

  1. Strength increases up to 19.7% compared to a placebo.
  2. Endurance increases after four weeks.
  3. Bone density increased by 1%.
  4. Improve power output up to 144%.
  5. Increase in performance up to 54%.
  6. Increase strength recovery by 47%.

PeptiStrong is derived using natural extraction. It prevents inhibition of muscle recovery by keeping the muscle you have and reducing the degradation and fatty change seen in aging. PeptiStrong may be a valuable aid in performance and recovery, rehabilitation, and anti-aging.

Probiotic Care Supports Healthy Outcomes for Mother and Infant

Posted on by Mike Miller

A team of researchers that investigated more than 960 studies of probiotic effects on maternity health and lactation concluded, “Recent evidence indicates that maternal-dietary intake, including dietary supplements, during pregnancy and lactation [has] implications for health outcomes in both the mother and infant.”1 Research from 967 studies with 29 randomized control trials, investigated the effects of probiotic, vitamin D, and lipid-based nutrient supplements on mother and infant gut microbiota. The data from these studies support significant reduction in mastitis of the nursing mother and increased bacterial diversity in the infant gut.2

Hereditum® LC40® Breastcare is a probiotic derived from breastmilk of healthy mothers. This probiotic is clinically supported to reduce occurrence of mastitis by 51% and a 66% reduction in recurrence. LC40® offers an effective alternative to the use of commonly prescribed antibiotics during lactation.3

Studies show breast milk is the best nutritional source for infants because it provides a unique combination of proteins, carbohydrates, lipids, minerals and vitamins. In addition the bioactive agents, and probiotic bacteria are responsible for a wide range of beneficial effects such as the promotion of immune system maturation and the protection against infections.4 A study conducted in New Zealand demonstrated that supplementation with Lactobacillus rhamnosus was associated with a significantly reduced risk of eczema in high-risk infants.5 Studies continue to support the benefits of probiotics for mother and infant.

Women’s Health is an Expanding Market

Posted on by Mike Miller

This supplement market overall is projected to expand at a 5.1% CAGR.  This includes hormonal aids, nutrition for fertility, menopause, and postnatal support. 

Postnatal supplements have a lucrative forecast with globally 41.8% of pregnant women suffering from anemia.  Supplements supporting anemia are omega-3 fatty acids, iron, vitamin D, folate, riboflavin, etc. The direct sales channels segment held the largest revenue share at 35.1%, likely due to consumer trust factor.

Postmenopause support dominated this market with a 32.6% share. Supplements include calcium, minerals, and vitamins D, B6, & E, Omega-3, Collagen, and Cucumber Extract for bone density and strength.

Grow Market Share with Vegan Collagen

Posted on by Mike Miller

Vegan collagen demand is projected to grow over 25% CAGAR to 2030.1  This is remarkable growth considering the collagen market continues to grow with 56% increase in sales in 2021 and an additional 28% in 2022.2 To catch this growth, companies that offer responsibly sourced, high quality collagen, coupled with the necessary vitamins and minerals needed for absorption will be positioned to grow their market share. 

Collagen (types I, II, & III)  are vital proteins needed for human connective tissues, such as skin, tendons, and joints make up from 25% to 35% of the whole body protein content.3  The body’s ability to produce collagen begins to drop at age 40. This drop in collagen continues and by age 80 the body is only able to produce less than 15% of the needed protein.4  

The need for collagen supplementation of types I, II, and III, together with vitamins C & D and the minerals zinc and copper provide for full absorption and benefit.5  As consumers age the need for collagen continues to grow. Companies that combine collagen systems with high quality types of collagen and the needed vitamins and minerals will be able to position themselves well in the growing market.

Anti-aging Market Opportunity

Posted on by FUEL

Looking and feeling good is about quality of life. As the population ages, the demand for improved health and quality of life is driving anti-aging product development. The anti-aging trend commonly used in the beauty industry, also includes the broader range of cellular health, bone and joint health, sleep wellness, and stress management. Consumers understand that beauty and health comes from within the body and they are seeking efficacious products that will improve their quality of life as they age.

As research continues, the demand for natural supplements that support functional-systems health continues to grow. The quest for youthful appearance and well-being is projected to grow at 6.8% CAGR 2023-2030.1 The anti-aging global market is projected to surpass 119.6 billion USD by 2030.2 Although North America dominated the anti-aging market in 2020, the Asia-Pacific region is expected to be the fastest growing market.3 This growth is expected to continue with the combination of increased life expectancy and the consumers’ interest in natural and organic products.

Companies that are able to introduce leading efficacious products to the marketplace are capturing market share and increasing their consumer sales. Plant Science continues to research and develop new and innovative products that enhance the consumer experience. Because of our on-going research and manufacturing capabilities, new product delivery can be available as soon as six weeks. This speedy time-to-market is important to growing a company’s market share.