Category: Research and Development Report

The Nutritional Combination Needed with Collagen for Efficacious Bone and Joint Health

Posted on by Mike Miller

Bone and joint nutritional support is needed earlier than most people realize. Joint issues begin in both men and women as early as 30-40 years of age. A flexibility study found that once men and women hit this age, flexibility drops significantly and unfortunately just keeps going down.1 

The need is increasing with the aging population for an efficacious supplement that supports bone and joint health through nutrition. Studies report the Collagen UC-II to be efficacious for the treatments of arthritis. A statistically significant improvement in knee joint function over a placebo was reported in a clinical study of  healthy individuals. The study also reported after 120 days of supplementation with UC-II collagen reported longer duration of strenuous exercise before transient knee joint pain was experienced.2  

However, collagen alone is only part of the nutritional requirement for joint and bone health. Studies show cartilage, bone density and strength are improved through a combination of nutrients, including: Collagen, Vitamin D, Zinc, and calcium.3  The uniqueness of this combination is that the nutritional elements actually aid in the absorption and effectiveness of each of the nutrients. In effect, it is through this combination that nutritional support for bone and joint health is improved.

Plant Science continues to evaluate studies in the development of efficacious supplements. The investment in research is important to the ongoing development of custom formulations.

Fiber the Nutrient of Concern

Posted on by Mike Miller

Although the mechanism for fiber’s health benefits is still not fully understood, studies demonstrate its value in supporting “digestive health and reduced risk for heart disease, stroke, hypertension, certain gastrointestinal disorders, obesity, type 2 diabetes, and certain cancers.”1

Although fiber in the form of intrinsic and functional, is found to have significant health benefits, an estimated 95% of American adults and children do not consume the recommended amounts of fiber.2 This gap in fiber consumption compared to the recommended intake has been identified by Dietary Guidelines for Americans as a “nutrient of concern.”3 

The probiotic formulation of MegaDuo™ contains Bacillus Coagulans SC208 and Bacillus Subtilis HU58. This Bacillus combination demonstrated reduced gut membrane barrier damage and decreased levels of the two cytokines TNFα and IL-6.44 These cytokines in high levels may lead to harmful gut inflammation. The potential benefits of MegaDuo™ were most evident after 2 weeks of treatment.

Research surveys indicate many people understand the importance and benefits of fiber in their diets, however the gap continues. This demonstrates the need for efficacious easy to consume supplements to support digestive health.

Source: Dysbiosis in An M-SHIME® Model”  Microorganisms: 2020 Jul 11; 8(7).

Tributyrin: Good Gut Bacteria

Posted on by Mike Miller

Research supports tributyrin supplementation improves microbial balance.1 This balance increases nutrient absorption, improves digestion, and reduces symptoms related to IBS or SIBO, including bloating, gas production, abdominal pain. Adequate intake of dietary fiber is supported by studies to reduce risk of heart disease, stroke, obesity and certain cancer.2

Tributyrin is a postbiotic found in butter and other dairy products. It is produced by the good bacteria known as Microbiome. Tributyrin brings 3 butyrate molecules to the digestive gut where they are separated and absorbed into the bloodstream. These molecules are transported throughout the body including the liver, brain, and lungs.

CoreBiome® is included in the Happy Gut capsule formulation, because it is the only tributyrin that has been clinically tested to substantiate bioavailability, reaching both the small and large intestines.3 This is important for delivery of an efficacious supplement. Because of the clinical testing, CoreBiome® is the only tributyrin with regulatory compliance to make marketable claims.4

The need for efficacious supplementation is evident with the dietary gap in US diets. Although fiber is found to have significant health benefits, an estimated 95% of American adults and children do not consume the recommended amounts of fiber.5 As part of Plant Science research and development, our scientists have evaluated building a supplement system that includes the triad of biotics, including: pre, pro, and post biotics. Because of this preliminary research investment, Plant Science is ready to develop custom formulations for your company’s consumers.

Source: Dysbiosis in An M-SHIME® Model”  Microorganisms: 2020 Jul 11; 8(7).

Exploring the Collagen-Boosting Potential of Tremella Mushroom

Posted on by Mike Miller

As we age, the body’s natural collagen production declines, leading to wrinkles, sagging skin and even joint stiffness.1

Collagen is a structural protein, essential for maintaining the health and integrity of our skin, bones and other connective tissue, like joints. Slowing down the natural decline of collagen production important to preserving human vitality. Tremella mushroom, also known as silver ear mushroom or snow fungus, is a wild, edible mushroom that has been traditionally used in Chinese medicine for its health benefits, including its potential to boost collagen production.2

Shown to have better moisture retention than hyaluronic acid, Tremella mushroom offers natural polysaccharides that have significant effect on increasing collagen production in human skin fibroblasts.3 Additionally, reports have found that tremella mushroom extract protects against ultraviolet B-induced photoaging by regulating the expression of matrix metalloproteinases and type I procollagen.4 Oxidative stress and inflammation can contribute to breakdown of collagen in the body. Furthermore, the rich antioxidant properties of tremella mushroom may contribute to its support of skin, bone and joint health.5

In our recent vegan collagen booster formula, tremella mushroom is paired with other known skin health ingredients, such as: l-lysine, bamboo silica, Yuth ™, acerola cherry, sea buckthorn polyphenols and a hydration complex to offer a tasty, low-dose, RTD mix that everyone (vegan or not) can enjoy!

Broccoli: A Valuable Source Of Sulforaphane

Posted on by FUEL

As research continues on the value of Sulforaphane (SFN) in the reduction of carcinogenesis and the proliferation of cancer cells, broccoli as a rich source of the organosulfur compound is projected to grow at a 4% CAGR to 2027.1

Based on genetic varieties and agricultural seasons, studies support broccoli seeds as the densest plant source of the compounds.2 As a result, consumers are seeking organic, clean, and easy to consume broccoli extract.

Sulforaphane studies have demonstrated its effect on the early stages of cancer. SFN appears to regulate cancer initiation phases by blocking DNA damage that initiates the growth of mutated cells, which form premalignant lesions.3 Cancer progression is an accumulation of cellular alterations, of which SFN may disrupt at early stages. This supports consumption of SFN through broccoli extracts as a valuable dietary source to lower the risk of cancer.

Plant Science continues to research and develop efficacious products that will benefit health and well-being. Because of this on-going research, our team of scientists are able to develop efficacious supplement products quickly for your market. Plant Science is able to develop and manufacture new products in as little as six weeks.

D-Serine May Reduce the Effects of Aging

Posted on by Mike Miller

Aging and cognitive decline is growing in the U.S., with projections of 89 million people suffering from age-associated dementias by 2050.1

A recent study published in PLOS Biology found that D-serine supplementation helped mitigate some of the age-related changes associated with a decline of the hypothalamic hormone Menin in mouse models. The study’s authors suggest that the decline of Menin expression in the hypothalamus with age may be one of the driving factors of aging, and D-serine is a potentially promising therapeutic for cognitive decline.2 

The need for natural health supplements that support reduction in age-related dementia are growing. One natural amino acid that is gaining traction in studies, is D-Serine. D-Serine is found naturally in nuts, especially peanuts, almonds, and walnuts and also found in eggs, chickpeas, lentils, and especially shellfish.3 D-Serine is localized in the forebrain and hippocampus and is considered to be important in maintaining healthy brain transmission and plasticity.4 

As research continues to grow with D-Serine, early studies demonstrate its effectiveness in relieving symptoms of schizophrenia.5 The use of D-Serine has been effective in improving motor and behavioral symptoms in Parkinson’s patients. Studies also support its benefit in relieving depression.6

Our most recent product development, “Anti-aging Pink Drink,” includes D-Serine in the formulations. Plant Science continues to research trends and studies to develop efficacious natural supplements that will aid in natural health and well-being.

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