Research & Development Report

D-Serine May Reduce the Effects of Aging

Aging and cognitive decline is growing in the U.S., with projections of 89 million people suffering from age-associated dementias by 2050.1

A recent study published in PLOS Biology found that D-serine supplementation helped mitigate some of the age-related changes associated with a decline of the hypothalamic hormone Menin in mouse models. The study’s authors suggest that the decline of Menin expression in the hypothalamus with age may be one of the driving factors of aging, and D-serine is a potentially promising therapeutic for cognitive decline.2 

The need for natural health supplements that support reduction in age-related dementia are growing. One natural amino acid that is gaining traction in studies, is D-Serine. D-Serine is found naturally in nuts, especially peanuts, almonds, and walnuts and also found in eggs, chickpeas, lentils, and especially shellfish.3 D-Serine is localized in the forebrain and hippocampus and is considered to be important in maintaining healthy brain transmission and plasticity.4 

As research continues to grow with D-Serine, early studies demonstrate its effectiveness in relieving symptoms of schizophrenia.5 The use of D-Serine has been effective in improving motor and behavioral symptoms in Parkinson’s patients. Studies also support its benefit in relieving depression.6

Our most recent product development, “Anti-aging Pink Drink,” includes D-Serine in the formulations. Plant Science continues to research trends and studies to develop efficacious natural supplements that will aid in natural health and well-being.

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1
Vincent GK Velkoff, “The Next Four Decades: The Older Population in the United States: 2010 to 2050,” U.S. Department of Commerce Economics and Statistics Administration. May 2010.
2
Lige Lieng, et al, “Hypothalamic Menin regulates systemic aging and cognitive decline,” PLOS Biology, March 16, 2023, https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002033.
3
George M. Kapalka, “Depression,” in Nutritional and Herbal Therapies for Children and Adolescents, 2010.
4
Marion R. Van Horn, Mari Sild, and Edward S. Ruthazer, “D-serine as a gliotransmitter and its roles in brain development and disease,” PubMed Central, Apr 23, 2013, PMID:23630460.
5
K. Johnson, etal, “Glutamate receptors as therapeutic targets for Parkinson’s disease,” CNS Neurol Disord Drug Targets, 2009, 475–491.
6
Horn, “D-serine as gliotransmitter.”
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