NAD efficiency is increased with RiaGev™

RiaGev is a proprietary compound that has demonstrated enters the NAD+ pathway directly and increases efficiently throughout the body, including muscle and brain.

Nicotinamide adenine dinucleotide (NAD) is a co-factor in the metabolic process and is a crucial element for life and everyday health. Levels of NAD in the body decrease naturally as we age. It declines faster when we are under stress, in an obese state or with any type of disease. Evidence accumulated in the last decade has demonstrated that decreased levels of NAD are correlated with health issues including cognitive decline, neurological disorder, mitochondrial dysfunction, metabolic imbalance and possibly a shortened healthy lifespan.

NAD+ is pivotal for cell life—first as a reusable coenzyme for redox reaction and energy production, second as a consumable substrate in enzymatic reactions regulating crucial biological processes including gene expression, DNA repair, cell death and lifespan, calcium signaling, glucose homeostasis, and circadian rhythms. 

As coenzymes, NAD+ and its related metabolites NAD+H, NAD+P+, and NAD+PH, participate in over 60% of the reactions in cellular metabolism. And their homeostasis is the determinant for oxidation versus reduction and anabolism versus catabolism balances. As a consumable substrate, NAD+ concentration is directly linked with aging and fat composition. And NAD+-consuming enzymes, including PARPs, sirtuins, and CD38, have wide-spread ramification for health and disease. 

The experiment demonstrated that RiaGev effectively increases NAD+, including NAD+, MNN, and NR, levels in the body. For all the organs and tissue analyzed, a positive dose-response occurs between RiaGev and NAD+ metabolites content. The five-day time course experiment indicates that RiaGev increased NAD+ levels and it reached its plateau in blood after four days (8 doses) of oral supplementation.