Research & Development Report

PI2 is a natural appetite suppressant

The active molecule in Slendesta is a well-studied protein called Proteinase Inhibitor II (PI2). PI2 works by promoting and extending the body’s natural release of cholecystokinin (CCK), a powerful peptide that signals key organs, including the stomach and brain, to induce feelings of fullness.

Researchers have discovered russet potatoes have naturally occurring higher levels of P12. Slendesta®, is a clinically tested natural and tested potent ingredient derived from natural potatoes. Clinical studies support this peptide as a game-changer in the realm of weight loss by offering a unique solution to the perennial challenge of controlling appetite. Its key mechanism lies in the activation of cholecystokinin (CCK), a hormone that signals fullness to the brain. By promoting the release of CCK, Slendesta® can induce a profound sense of satiety, and can also help by curbing hunger pangs and reducing the temptation to overeat. This natural approach to appetite control makes Slendesta® an invaluable component in weight management strategies, empowering individuals to make sustainable lifestyle choices by fostering a feeling of fullness that lasts beyond mealtimes. With its ability to support portion control and minimize unnecessary snacking, Slendesta® plays a pivotal role in creating a more balanced and mindful approach to eating, facilitating a healthier and more sustainable weight loss journey.

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1
Dana, S. et. al. Slendesta potato extract promotes satiety in healthy human subjects: Iowa State University (ISU) study. Kemin Health Technical Literature KHBB-017-050, 2006.
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Dana, S. A randomized, double-blind, placebo-controlled clinical study demonstrates Slendesta Potato Protein Extract is a safe and effective tool for promoting weight reduction. Kemin Health Technical Literature KBB-017-044, 2006.
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Dana, S. A 20-week open-label clinical study shows Slendesta Potato Protein Extract is effective for weight loss and improved body measurements. Kemin Health Technical Literature KHBB-017-045, 2006.
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The Kemin Foods, L.C. definition of a “natural” ingredient is an ingredient with the identical molecular structure and characteristics as found in nature. The ingredient is derived solely from a plant, animal or mined sources, either in an unprocessed state or having been subject to moderate processing (physical processing, heating processing, purification, hydrolysis, extraction, drying). The ingredient does not contain any additives, except in amounts that might occur unavoidably during good manufacturing practices or good farming practices as applicable.
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Holt et al., Eur J Clin Nutr. 49 (9): 675-90.
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Spreadbury D. et al. A proteinase inhibitor extract from potatoes reduces post-prandial blood glucose in human subjects. JANA 6: 29-38, 2003.
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Hu, J. et al. (2013). GRAS Status for Slendesta® Potato Extract. Kemin Health Technical Literature KHBB-017-071.
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